abstract：:all-trans-Retinoic acid (ATRA) induces complete remission in majority of patients with acute promyelocytic leukemia (APL). However, accelerated metabolism of ATRA that is induced by chronic daily administration of oral ATRA has been implicated as one of the mechanisms leading to a reduced sensitivity or resistance to ...

journal_title：American journal of hematology

authors： Ozpolat B,Mehta K,Tari AM,Lopez-Berestein G

更新日期：2002-05-01 00:00:00

abstract：:Red blood cell (RBC) autoantibodies are a relatively uncommon cause of anemia. However, autoimmune hemolytic anemia (AIHA) must be considered in the differential diagnosis of hemolytic anemias, especially if the patient has a concomitant lymphoproliferative disorder, autoimmune disease, or viral or mycoplasmal infecti...

journal_title：American journal of hematology

authors： Gehrs BC,Friedberg RC

更新日期：2002-04-01 00:00:00

abstract：:Hemoglobin Lyon-Bron was found in two members of a family of German ascent presenting with a moderate normocytic anemia. In this alpha 2 globin variant, the N-terminal valine of the chain was replaced by an alanine. Electrospray mass spectrometry of the alpha chain showed that, as normally, the initiator methionine wa...

journal_title：American journal of hematology

authors： Lacan P,Souillet G,Aubry M,Promé D,Richelme-David S,Kister J,Wajcman H,Francina A

更新日期：2002-03-01 00:00:00

abstract：:We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic throm...

journal_title：American journal of hematology

authors： Ergas D,Tsimanis A,Shtalrid M,Duskin C,Berrebi A

更新日期：2002-02-01 00:00:00

abstract：:Complete remission can be achieved in 60-80% of adults with diffuse aggressive non-Hodgkin's lymphoma. However, 20-40% of them will subsequently relapse. Nevertheless, formal follow-up guidelines for recurrence detection have never been advocated. We analyzed the pattern of relapse in 30 patients with intermediate- an...

journal_title：American journal of hematology

authors： Elis A,Blickstein D,Klein O,Eliav-Ronen R,Manor Y,Lishner M

更新日期：2002-01-01 00:00:00

abstract：:At sites of vascular injury, the platelet collagen receptor Glycoprotein Ia/IIa (GPIa/IIa) acts as an important mediator of platelet adhesion to fibrillar collagens. Two silent polymorphisms (807C/T and 873G/A) within the glycoprotein Ia gene have been implicated in increased risk of developing thrombosis and myocardi...

journal_title：American journal of hematology

authors： Komurcu E,Erginel-Unaltuna N

更新日期：2002-01-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a Kunitz-type proteinase inhibitor that has a crucial role in haemostasis and is primarily synthesized in the vascular endothelium. We investigated plasma total TFPI, antiphospholipid antibodies, and some other coagulation and fibrinolytic system parameters in 30 patients with...

journal_title：American journal of hematology

authors： Akarsu M,Demirkan F,Ozsan GH,Onen F,Yüksel F,Ozkan S,Undar B

更新日期：2001-12-01 00:00:00

abstract：:We report a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who presented with rapid enlargement of a cervical lymph node due to localized herpes simplex lymphadenitis, which was clinically indistinguishable from large cell (Richter's) transformation. The diagnosis was made by excisional...

journal_title：American journal of hematology

authors： Joseph L,Scott MA,Schichman SA,Zent CS

更新日期：2001-12-01 00:00:00

abstract：:We describe two patients with mild hemophilia A (MHA) who developed high titer inhibitor (HTI) following intensive recombinant factor VIII (rFVIII) concentrate replacement for surgery and trauma. Intranasal desmopressin was instituted shortly following immunosuppressive therapy (IST) and activated prothrombin complex ...

journal_title：American journal of hematology

authors： Robbins D,Kulkarni R,Gera R,Scott-Emuakpor AB,Bosma K,Penner JA

更新日期：2001-11-01 00:00:00

abstract：:The specificity of autoantibodies in autoimmune hemolytic anemia (AIHA) has been studied using the serological procedure and immunoprecipitation technique with rare phenotype red cells. We attempted to analyze specificity using recombinant rhesus (Rh) blood group and band3 antigens expressed on erythroleukemic cell li...

journal_title：American journal of hematology

authors： Iwamoto S,Kamesaki T,Oyamada T,Okuda H,Kumada M,Omi T,Takahashi J,Tani Y,Omine M,Kajii E

更新日期：2001-10-01 00:00:00

abstract：:The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes in the same patient. We evaluated the potential bene...

journal_title：American journal of hematology

authors： Emmenegger U,Frey U,Reimers A,Fux C,Semela D,Cottagnoud P,Spaeth PJ,Neftel KA

更新日期：2001-09-01 00:00:00

abstract：:Pancytopenia is a rare complication of the thionamide therapy reported secondary to aplastic anemia, the bone marrow being invariably hypocellular. We present a case of a 16-year-old female with Graves' disease who presented with massive bone marrow plasmocytosis mimicking multiple myeloma. The patient had already bee...

journal_title：American journal of hematology

authors： Breier DV,Rendo P,Gonzalez J,Shilton G,Stivel M,Goldztein S

更新日期：2001-08-01 00:00:00

abstract：:Hydroxyurea is a drug that is used to treat some patients with sickle cell disease. We have measured the deformability of sickle erythrocytes incubated in hydroxyurea in vitro and found that hydroxyurea acts to decrease the deformability of these cells. The deformability of normal erythrocytes was not significantly af...

journal_title：American journal of hematology

authors： Huang Z,Louderback JG,King SB,Ballas SK,Kim-Shapiro DB

更新日期：2001-07-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML), a demyelinating infectious disease caused by JC virus (JCV), occurs almost exclusively in immunocompromised patients usually with malignant diseases. We report here a Japanese female with follicular lymphoma who subsequently developed PML. In addition to JCV, human her...

journal_title：American journal of hematology

authors： Daibata M,Hatakeyama N,Kamioka M,Nemoto Y,Hiroi M,Miyoshi I,Taguchi H

更新日期：2001-07-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical efficacy and safety of the ultrasound-guided fine needle biopsy (UG-FNB) of the spleen in a large population of patients. We collected retrospectively the findings concerning the application of UG-FNB of the spleen from eight Italian clinical centers that utilized thi...

journal_title：American journal of hematology

authors： Civardi G,Vallisa D,Bertè R,Giorgio A,Filice C,Caremani M,Caturelli E,Pompili M,De Sio I,Buscarini E,Cavanna L

更新日期：2001-06-01 00:00:00

abstract：:The mechanism of multinucleated cell formation in Hodgkin's disease has not yet been elucidated. We asked whether the giant multinucleated cells of the H-RS cell line L1236 develop via fusion of the predominant smaller cells. As a positive control for the fusion assay, human B cells from the B-cell lymphoma cell line ...

journal_title：American journal of hematology

authors： Re D,Benenson E,Beyer M,Gresch O,Draube A,Diehl V,Wolf J

更新日期：2001-05-01 00:00:00

abstract：:Limited data are available regarding optimal treatment with desmopressin (DDAVP) or intermediate-purity FVIII concentrates rich in VWF (CFCs) in patients with von Willebrand disease (VWD) who undergo planned surgery. We undertook a retrospective review over 10 years (1988-1997) and identified 27 patients treated with ...

journal_title：American journal of hematology

authors： Nitu-Whalley IC,Griffioen A,Harrington C,Lee CA

更新日期：2001-04-01 00:00:00

abstract：:A 77-year-old man with relapsed non-Hodgkin's lymphoma, diffuse large B-cell type, was treated with naproxen, a nonsteroidal anti-inflammatory drug (NSAID), for paraneoplastic fever. A dramatic disappearance of not only the fever but also generalized lymphadenopathy was observed. Naproxen was continued, and he maintai...

journal_title：American journal of hematology

authors： Yoshinaga K,Teramura M,Iwabe K,Kobayashi S,Masuda M,Motoji T,Mizoguchi H

更新日期：2001-03-01 00:00:00

abstract：:A case of leukemia cutis (LC) of monocytic lineage in a patient with myelodysplastic syndrome (MDS) is presented. Cutaneous infiltrates were recognized concurrent with diagnosis of refractory anemia (RA) with monocytosis. Skin infiltrates subsequently spontaneously regressed although MDS progressed with increasing mon...

journal_title：American journal of hematology

authors： Yavorkovsky LL,Zain J,Wu CD,Trivelli L,Cook P

更新日期：2001-02-01 00:00:00

abstract：:A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detected, and a diagnosis of adult T-cell leukemia (ATL) was made. Flow cytometry revealed that the ATL cells expressed CD20 as well as T-cell-associated antigens, and expres...

journal_title：American journal of hematology

authors： Yasukawa M,Arai J,Kakimoto M,Sakai I,Kohno H,Fujita S

更新日期：2001-01-01 00:00:00

abstract：:Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its ligand stem cell facto...

journal_title：American journal of hematology

authors： Pullarkat VA,Pullarkat ST,Calverley DC,Brynes RK

更新日期：2000-12-01 00:00:00

abstract：:Hydroxyurea (HU) is a widely used cytotoxic agent that is known to induce fetal hemoglobin (HbF) production and is presently used to ameliorate the severity of pain episodes in patients with sickle cell anemia (HbSS). Previously we have shown that HU inhibits growth of burst forming unit-erythroid (BFU-E) colonies in ...

journal_title：American journal of hematology

authors： Baliga BS,Pace BS,Chen HH,Shah AK,Yang YM

更新日期：2000-11-01 00:00:00

abstract：:We evaluated possible prognostic factors just before salvage therapy with vincristine, doxorubicin, and dexamethasone (VAD) for 36 patients with refractory multiple myeloma. The median duration from diagnosis to the first VAD salvage was 14 months (range 2-76 months). Among parameters that have been shown to be associ...

journal_title：American journal of hematology

authors： Suguro M,Kanda Y,Yamamoto R,Chizuka A,Hamaki T,Matsuyama T,Takezako N,Miwa A,Togawa A

更新日期：2000-10-01 00:00:00

abstract：:A small number of thromboembolic events, including deep venous thrombosis and myocardial infarction, have been reported in patients receiving IVIG. These events have primarily occurred in patients receiving high-dose IVIG and have been attributed to an increase in blood viscosity. To test the hypothesis that a procoag...

journal_title：American journal of hematology

authors： Wolberg AS,Kon RH,Monroe DM,Hoffman M

更新日期：2000-09-01 00:00:00

abstract：:Fourteen patients, aged 65-85 years, with refractory (11) or relapsing (3) multiple myeloma were treated with a "protracted-sequential" protocol comprising vincristine 1-2 mg or vindesine 3 mg/M(2) (max. 5 mg) IVI over 4 hr on D1, prednisolone 40-50 mg PO D1-14, and melphalan 2-4 mg PO or cyclophosphamide 50-100 mg PO...

journal_title：American journal of hematology

authors： Manoharan A

更新日期：2000-09-01 00:00:00

abstract：:We have investigated whether the quantitative flow cytometry is an useful tool to better characterize B-cell chronic lymphoproliferative disorders (CLDs). Peripheral blood samples from 104 patients with leukemic B-cell disorders and 20 healthy donors were analyzed. Directly phycoerythrin-conjugated CD19, CD20, CD22, C...

journal_title：American journal of hematology

authors： D'Arena G,Musto P,Cascavilla N,Dell'Olio M,Di Renzo N,Carotenuto M

更新日期：2000-08-01 00:00:00

abstract：:If a translocation is followed by loss of one of the two derivative chromosomes, the result is an unbalanced translocation, showing monosomy for the segments making up the lost derivative. We have found that in most unbalanced translocations, a third event takes place: a morphologically normal copy of one of the two t...

journal_title：American journal of hematology

authors： Pedersen B,Nørgaard JM,Pedersen BB,Clausen N,Rasmussen IH,Thorling K

更新日期：2000-07-01 00:00:00

abstract：:The occurrence of factor VIII inhibitors in non-hemophilic patients is a rare event with a potentially lethal outcome. Despite its infrequent occurrence, the association of this inhibitor with multiple autoimmune diseases is well recognized. We report the case of a patient with the recently described autoimmune lympho...

journal_title：American journal of hematology

authors： Fang BS,Sneller MC,Straus SE,Frenkel L,Dale JK,Rick ME

更新日期：2000-07-01 00:00:00

abstract：:Twenty-eight patients undergoing cardiac surgery were prospectively studied and were assigned to two groups. The patients received 0.8- (Group L) or 2.0-fold (Group H) dose of protamine for the neutralization after cardiopulmonary bypass (CPB) which was determined by Hepcon HMS(R) assay system in which the reagent cha...

journal_title：American journal of hematology

authors： Miyashita T,Nakajima T,Hayashi Y,Kuro M

更新日期：2000-06-01 00:00:00

abstract：:Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement. The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia. Hematopoietic growth factors serum levels were measured by ELISA technique in forty-eight...

journal_title：American journal of hematology

authors： Marta RF,Enria D,Molinas FC

更新日期：2000-05-01 00:00:00

abstract：:We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-1 proviral DNA in the peripheral mononuclear cells by means of polymerase chain reactio...

journal_title：American journal of hematology

authors： Nakase K,Hasegawa M,Tsuji K,Ikeda T,Tamaki S,Tanigawa M,Miyanishi E,Shiku H

更新日期：2000-05-01 00:00:00

abstract：:Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F-cells. Fetal hemoglobin (Hb F) inhibits the polymerization events of sickle hemoglobin (Hb S), thereby ameliorating the clinical symptoms of sickle cell disease. Ribonucleotide reductase inhibitors (RRIs) ...

journal_title：American journal of hematology

authors： Iyamu WE,Adunyah SE,Fasold H,Horiuchi K,Elford HL,Asakura T,Turner EA

更新日期：2000-04-01 00:00:00

abstract：:The detection and identification of blood group antibodies in patients is crucial for successful allogeneic blood transfusions. Current methods are highly subjective and rely on red blood cells (RBCs), which simultaneously express many blood group antigens, have a short shelf-life, and carry potential biohazard risks....

journal_title：American journal of hematology

authors： Yazdanbakhsh K,Oyen R,Yu Q,Lee S,Antoniou M,Chaudhuri A,Reid ME

更新日期：2000-03-01 00:00:00

abstract：:In this study we investigated the possible role of neutrophil (PMN) elastase and its natural inhibitor, alpha1-proteinase inhibitor (alpha1-PI) in the pathogenesis of the pseudoxanthoma elasticum (PXE)-like syndrome which is found in patients with homozygous beta-thalassemia. We studied 30 beta-thalassemia homozygotes...

journal_title：American journal of hematology

authors： Samarkos M,Aessopos A,Fragodimitri C,Karagiorga M,Kalotychou V,Voskaridou E,Kavouklis E,Loukopoulos D

更新日期：2000-02-01 00:00:00

abstract：:We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

journal_title：American journal of hematology

authors： Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

更新日期：2000-01-01 00:00:00

abstract：:In southeast Asia, the carrier frequency of two-gene alpha-thalassemia deletions is quite high, ranging from 4% to 14% depending on the population. The most common alpha-thalassemia-1 deletion is the so-called southeast Asian deletion (--(SEA)). In addition, a significant proportion of cases involve two other deletion...

journal_title：American journal of hematology

authors： Eng B,Patterson M,Borys S,Chui DH,Waye JS

更新日期：2000-01-01 00:00:00

abstract：:Lymphomatoid granulomatosis (LG) is an uncommon but potentially fatal disease. The disease primarily involves the lungs; however, skin, renal, and central nervous system (CNS) are seen in varying proportions. Neurological involvement occurs in one third of the patients, and confers a worse prognosis. The use of radiot...

journal_title：American journal of hematology

authors： Petrella TM,Walker IR,Jones GW,Leber B

更新日期：1999-12-01 00:00:00

abstract：:Familial and metachronous aggregations of malignant lymphoma are well-documented, but the molecular basis of a predisposition for development of lymphoma is as yet unclear. Malignant lymphomas have been described as part of the spectrum of neoplasias in Li-Fraumeni syndrome (LFS), which is associated with constitution...

journal_title：American journal of hematology

authors： Pötzsch C,Schaefer HE,Lübbert M

更新日期：1999-11-01 00:00:00

abstract：:Acquired pure megakaryocytic aplasia is a rare disorder defined by severe thrombocytopenia with no other hematologic abnormalities and absent, or severely decreased marrow megakaryocytes. The etiology may be immune suppression of megakaryocyte development. Two patients are described who both responded rapidly to a com...

journal_title：American journal of hematology

authors： Leach JW,Hussein KK,George JN

更新日期：1999-10-01 00:00:00

abstract：:A single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR)-amplified products of immunoglobulin (Ig) heavy chain rearrangements can be used to analyze B cell clonalities and clonal identities of B cells from different samples. However, the usefulness of the PCR-SSCP analysis is not fu...

journal_title：American journal of hematology

authors： Shiokawa S,Nishimura J,Uike N,Saburi Y,Suehiro T,Yamamoto K

更新日期：1999-10-01 00:00:00